Protein Details: Gamma-aminobutyric acid receptor subunit beta-3

Protein ID

ICDB_Pro_0381

Protein Name

Gamma-aminobutyric acid receptor subunit beta-3

Gene Name

GABRB3

Organism

Gallus gallus (Chicken)

Length

476 amino acids

AlphaFoldDB

AF-P19019-F1-model_v4.pdb

Function

Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA); a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels; also named GABA(A) receptors (GABAAR); consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA; GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential; thereby reducing nerve transmission. GABAARs containing beta-3 subunits exhibit synaptogenic activity (By similarity). Extrasynaptic beta-3 receptors contribute to the tonic GABAergic inhibition (By similarity). Beta-containing receptors can also function as histamine receptor where histamine binds at the interface of two neighboring beta subunits (By similarity).

Sequence

MWGFGGGRIFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYAGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDNAVTGVERIELPQFSIVEYRLVSKNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGKGPQRQKKLAEKSAKANNDRSRFEGSRVDTHGNILLTSLEIHNEVASNEVTTSVTDARNSTISFDNSGIQYRKQSSHRESLGRRSSDRTGSHSKRGHLRRRSSQLKIKIPDLTDVNAIDRWSRMVFPFTFSLFNLIYWLYYVN

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 122; /ligand="histamine": "ligand shared between two neighboring beta subunits"; /note="in chain B"; BINDING 180; /ligand="4-aminobutanoate": "ligand shared with the neighboring alpha subunit"; /note="in chain A"; BINDING 181..182; /ligand="histamine": "ligand shared between two neighboring beta subunits"; /note="in chain B"; BINDING 182; /ligand="4-aminobutanoate": "ligand shared with the neighboring alpha subunit"; /note="in chain A"; BINDING 227; /ligand="4-aminobutanoate": "ligand shared with the neighboring alpha subunit"; /note="in chain A"; BINDING 227; /ligand="histamine": "ligand shared between two neighboring beta subunits"; /note="in chain B"

Disease

Location

DOI ID

10.1093/nar/18.18.5557

RefSeq

NP_990677.1